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UW-Madison expands COVID-19 sequencing, joining global project to improve pandemic response
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UW-Madison expands COVID-19 sequencing, joining global project to improve pandemic response

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More than 101 million Americans are now fully vaccinated against the coronavirus. 

UW-Madison professors at the forefront of sequencing COVID-19 strains in the community are expanding their research tracking the virus’ spread while fostering closer ties with more public health agencies with the hope of improving future pandemic response.

The university is joining more than 20 public, private and nonprofit partners as part of a newly announced Pandemic Prevention Institute that will establish hubs across the country to sequence COVID-19 samples in specific regions. UW-Madison professors will lead the Upper Midwestern hub. As a part of the broader network, UW will partner with researchers at the Massachusetts Institute of Technology, Harvard, Louisiana State University and the University of Florida.

“The goal is to foster better connections between academic scientists and public health experts so that advances in viral genomic sequencing can be translated into more effective public health measures,” UW pathology professor Thomas Friedrich said. “The hope is to build infrastructure that will be sustainable and able to respond to future pandemics.”

The project is privately funded by the Rockefeller Foundation for one year, but the hope is that it will eventually lead to federal funding, Friedrich said.

OConnor and Friedrich

UW-Madison researchers David O'Connor, left, and Tom Friedrich are members of the team for the new Pandemic Prevention Institute.

Genomic sequencing conducted by Friedrich, along with his colleagues Shelby O’Connor and her husband, David O’Connor, will support the Prevention Institute’s mission of identifying and tracking outbreaks and variants, while also creating a network of researchers and medical professionals to increase information sharing with local health departments, which hasn’t historically been the approach between those entities.

More than 101 million Americans are now fully vaccinated against the coronavirus. 

“We as researchers can learn a lot about the way that public health agencies have to communicate to the public, and we need to learn how to make our science help them communicate best,” Shelby O’Connor said. “Having more people who are capable of spanning both the academic and public health [fields] is going to be really helpful for future pandemics.”

Having open lines of communication can also quicken pandemic response, David O’Connor said. Simple testing identifies if an individual is infected with COVID-19, while sequencing pinpoints the specific variant. This information is key because different variants behave differently, requiring different public health responses.

David O'Connor at computer

Shelby and David O'Connor have been conducting genomic sequencing research throughout the pandemic.

The need for adaptive behaviors was evident earlier in the spring when the first cases of the variant COVID strain, B.1.1.7 were found in Dane County, he said.

“It acted as sort of a ‘scared straight’ program,” David O’Connor said. “When people found out there was a cluster involving one of these variants of concern, they were very reactive and did intensify behaviors that frankly had become a little bit lax as the pandemic progressed.”

With cases in Dane County on the decline, he said he hopes to use the Rockefeller grant to conduct research that is “forward looking” and includes school-age children. Researchers have been working with the city-county health department to test children under 12 because many children in that age group may not be vaccinated until 2022.

David O'Connor and Gage Moreno

David O’Connor, left, confers with graduate student Gage Moreno at the lab.

“When school starts again ... kids could play a greater role in transmission and evolution of the virus, and so we want to make sure we can track that,” Friedrich said. “We also want to get more representative samples throughout the state.”

To ensure the world is better prepared for the next pandemic, Shelby O’Connor said the project’s regional sequencing hubs will be just one part of a broader response.

“I’d like to think that trying to set these up will help put us in a better place for genomic surveillance a year from now but whether that actually means we will have a better coordinated response across all elements of public health is a totally different question and we’re not gonna know that for a while,” she said. “Hopefully we will learn from our mistakes and have a better response in the future.”

David O’Connor said support and funding for projects like this needs to be sustainable beyond the pandemic.

“The question is, 10 years from now how much are people going to remember about this, and how durable are these lessons going to be?”


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