The Bills have opened as a seven-point favorite over the Indianapolis Colts for next weekend's wild-card game.
The game is scheduled for Saturday at 1:05 p.m. at Bills Stadium.
The last time the Bills were favored in the playoffs was in 1995, when they were favored by three at home against Miami in a 37-22 win.
While the Bills have lost their last six playoff games in a row, they are 10-1 straight up and 7-3-1 against the spread as a playoff favorite since 1989.
In other AFC games, Pittsburgh opened as a four-point favorite against Cleveland, and Baltimore opened as a 3 1/2-point favorite at Tennessee.
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